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21세기 첨단과학의 꽃 Life Science
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02-6490-2660~1
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Lab of Neuroscience
Professor : Yun Doo Chung
Tel : +82-2-6490-5626
Location : Natural Science Building Room 8-307
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  • We are focusing on two main research topics using the fruitfly, Drosophila melanogaster, as a model system.


    I. Mechanosensory transduction

    Our senses of touch, hearing and proprioception are conferred by mechanosensory transduction. One of the main interests of our laboratory is to understand the molecular mechanisms underlying sensory mechano-transduction. It has been generally believed that two subfamiles of TRP ion channels (TRPN and TRPV) are involved in transducing mechanical stimuli to neuronal action potentials in Drosophila type I mechanosensory cells. In our lab, we are studying the specific roles of the TRP channels by using molecular genetic, imaging and electrophysiological approaches. In addition to the roles of TRP channels, we are also interested in NOMPA, an extracellular matrix protein required for the organization of the dendritic cap or sheath. By using transgenic flies expressing various modified version of NOMPA, we are currently testing a possible interaction of NOMPA with TRP channels.


    II. In vivo roles of metazoan THO complex

    Gene expression in eukaryotic cells requires the coordinated control of mRNP biogenesis at multiple levels including transcription, processing and nuclear export. It has been known that an evolutionary conserved protein complex, THO complex, is involved in the biogenesis of mRNP at post-transcriptional level. Although it has been recently studied extensively on the roles of THO complex on mRNA biogenesis in yeast and mammalian cells in culture, its specific roles at multicellar organism level are still unclear. Thus understanding the in vivoroles of THO complex in animal model is another main interest of our laboratory. By using mutant flies, we found several specific defects (e.g., male sterile, wing blister, reduced life span etc) caused by lack of THO complex, suggesting THO complex is required for the expression of specific genes. We are currently investigating the specific signaling pathways involved in THO function.


▷ Selected publications

Moon S and Chung YD (2013) p53 and PI3K/AKT signalings are up-regulated in flies with defects in the THO complex. Mol. Cells. In press.
Moon S, Cho B, Min SH, Lee D and Chung YD (2011) The THO complex is required for nucleolar integrity in Drosophila spermatocytes. Development 138: 3835-45.
Kim H, Cho B, Moon S and Chung YD (2011) The THO complex is required for stress tolerance and longevity in Drosophila. Genes Genomics 33: 291-7
Lee J, Moon S, Cha Y and Chung YD (2010) Drosophila TRPN(=NOMPC) channel localizes to the distal end of mechanosensory cilia. PLoS One 5:e11012.
Son W, Han PL and Chung YD (2008) The adenylyl cyclase encoded by rutabaga is required for larval molting in Drosophila. Genes Genomics 30: 163-71.
Chung YD (2007) Mechanosensory transduction in Drosophila melanogaster. Kor. J. Genet. 29: 419-26.
Gong ZF, Son W, Chung YD, et al (2004) Two interdependent TRPV channel subunits, inactive and Nanchung, mediate hearing in Drosophila. J. Neurosci. 24: 9059-66.
Kim J, Chung YD, et al (2003) A TRPV family ion channel required for hearing in Drosophila. Nature 424: 81-4.
Chung YD, Zhu JC, Han YG and Kernan MJ (2001) nompA encodes a PNS-specific, ZP domain protein required to connect mechanosensory dendrites to sensory structures. Neuron 29: 415-28.


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